Human Sera
Perkin Elmer US LLC Portability Pack for the Spectrum Two
The PerkinElmer Spectrum Two is a robust and transportable FT-IR system platform enabling simple, reliable FT-IR solutions for product quality testing. A range of plug-and-play sampling accessories and application packages ensure the best solution for a range of applications. Whatever your specific IR analysis requirements, the Spectrum Two delivers outstanding performance and reliability to provide high-performance, dependable IR measurement solutions.
Cayman Chemical FruquIntInIb 50mg
A truncated form of rat adrenomedullin decreases mean systemic arterial pressure in rats from 3-10 g/animal reduces water intake in response to angiotensin II overnight water deprivation and hyperosmotic challenge in rats at 88 pmol
Cayman Chemical N2Isobutyryl5O 4 4dIme 100mg
A steroid saponin with anticancer activity decreases proliferation of and apoptosis in MCF-7 and MDA-MB-231 cells (IC50s 5 and 2 5 UM respectively) disrupts the mitochondrial membrane potential activates caspase-3 and increases protein levels of PARP in HepG2 and R-HepG2 cells reduces tumor growth in an MCF-7 mouse xenograft model at 2 05 and 2 73 mg/kg for 10 days
Cayman Chemical PropentofylIn 50mg
A phenylethanoid with diverse biological activities scavenges DPPH radicals in a cell-free assay (IC50 11 8 UM) inhibits 5- and 15-LO (IC50s 0 375 and 96 UM respectively) decreases viability of TE-1 ESCC cells at 20-320 Ug/ml as well as inhibits LPS-induced EMT in Eca-109 and TE-1 cells and decreases phosphorylated NF-KB levels in TE-1 cells inhibits arachidonic acid-induced mouse ear edema at 3 mg/ear
Cayman Chemical Benzyl2ACTAmIdo2deoxya 50mg
A mitochondrial complex I inhibitor and inducer of ferroptosis decreases ATP-dependent luciferase reporter activity and ATP levels in H1299luc cells induces production of ROS increases a-tocopherol-sensitive lipid peroxidation and decreases GSH levels in SK-MEL-28 and G361 melanoma cells reduces tumor weight HIF-1a levels and HIF-1a target gene expression in an H460 mouse xenograft model from 0 5-4 mg/kg reduces tumor growth in the MEXF 276 and MEXF 1732 melanoma PDX mouse models
Cayman Chemical N2Isobutyryl5O 4 4dIme 50mg
A chromogenic substrate for N-acetyl-b-glucosaminidase hydrolysis of 4-nitrophenyl-N-acetyl-b-D-glucosaminide by N-acetyl-b-glucosaminidase releases 4-nitrophenol which can be quantified by colorimetric detection at 405 nm as a measure of N-acetyl-b-glucosaminidase activity has been used to quantify the activity of N-acetyl-b-D-glucosaminidase in human serum and urine in parenterally fed patients
Cayman Chemical DrospIrenon 50mg
An inhibitor of IRE1a inhibits ER stress induced XBP1 splicing and reduces expression of the XBP1 target genes SEC61A1 p58IPK and ERdj4 in RPMI 8226 cells cytotoxic to multiple myeloma cell lines but has no effect on normal mononuclear cells reduces tumor growth and XBP1 splicing in an RPMI 8226 mouse xenograft model (100 mg/kg)
Cayman Chemical 5 Hydroxymethyl2deoxyurI 100mg
A HIF-2a inhibitor (IC50 12 nM) inhibits HIF-2a-induced transcription of intratumoral Vegfa mRNA and reduces tumor volume in a 786-O mouse xenograft model at 10 mg/kg inhibits the production of sFlt1 and prevents the development of hypertension and proteinuria markers of preeclampsia in pregnant rat dams at 20 mg/kg
Cayman Chemical 4NItrophenyl DCelobIosId 100mg
A PCAF bromodomain inhibitor (Kd 126 nM) selective for PCAF over GCN5 (Kd 600 nM) 4500-fold selective for PCAF over BRD4 displaces the PCAF bromodomain from histone H3 3 in a nanoBRET target engagement assay at 5 M
Cayman Chemical 3-Methylcrotonyl GlycIn 50mg
A calcium channel inhibitor binds to calcium channels in isolated rat ventricular membranes (Kd 0 04 nM) and inhibits calcium uptake by smooth muscle cells reduces ventricular tachycardia and fibrillization and increases survival in a rat model of ventricular arrhythmias induced by myocardial ischemia at 3 mg/kg dietary administration reduces reduces systolic blood pressure in spontaneously hypertensive rats at 50 and 100 mg/kg
Cayman Chemical TosufloxacIntosylate 100mg
A selective eEF-2K inhibitor (IC50 440 nM) disrupts the proliferation of HepG2 and HCT116 tumor cells (EC50s 2 07 and 230 UM respectively) with low mitochondrial toxicity
Cayman Chemical MetaramInoltartrate 50mg
A benzoxaborole compound that displays broad antifungal effectiveness in vitro inhibits LeuRS from molds and yeasts (IC50s 2 and 4 2 UM for A fumigatus and C albicans LeuRS respectively)
Cayman Chemical EmedastInfumarate 50mg
A pyrimidine nucleoside forms complementary base pairs with adenosine in RNA replaced with thymidine in DNA